Viruses Genetically Engineered to Kill Bacteria Rescue Girl with Antibiotic-Resistant Infection
May 8, 2019
(Science) – With the standard treatments failing, Isabelle’s mother asked Spencer about alternatives—adding that she had read something about using viruses to kill bacteria. Spencer decided to take a gamble on what seemed like a far-fetched idea: phages, viruses that can destroy bacteria and have a long—if checkered—history as medical treatments. She collaborated with leading phage researchers, who concocted a cocktail of the first genetically engineered phages ever used as a treatment—and the first directed at a Mycobacterium, a genus that includes tuberculosis (TB). After 6 months of the tailor-made phage infusions, Isabelle’s wounds healed and her condition improved with no serious side effects, the authors report today in Nature Medicine.