Potential Use of Human Stem Cell-Derived Intestinal Organoids to Study Inflammatory Bowel Disease
August 31, 2018
(Inflammatory Bowel Diseases) – In this review, we provide an overview of the versatility of human organoid cultures in IBD modeling. We discuss recent advances and current limitations in the application of this tool for modeling the contribution of the intestinal epithelium alone and in combination with other key cellular and molecular players in the context of IBD pathophysiology. Finally, we outline the pressing need for technically standardizing the laboratory manipulation of human epithelial organoids for their broader implementation in clinically oriented IBD studies.