Whether the Donor and Recipient Are Male and Female Influences Transplant Rejection Rates–Investigators Explore Why
March 23, 2018
(Medical Xpress) – Biological sex differences can have far-reaching, clinical consequences, as illustrated by organ transplant outcomes. Men and women who receive donated organs can have different rates of transplant rejection, in some cases influenced by the sex of the donor. In general, the influence of biological sex on transplant outcomes has not been rigorously studied and largely underappreciated. A new study by investigators at Brigham and Women’s Hospital assesses what is currently known about the influence of biological sex differences, possible mechanisms that may explain discrepancies between rejection rates for male and female recipients and what questions remain to be explored in future studies.