Scientists Use CRISPR to Turn Genes on [in Mice] Without Editing Their DNA

December 7, 2017

(Los Angeles Times) – The revolutionary gene editing tool CRISPR-Cas9 is best-known for helping scientists edit a strand of DNA more precisely and efficiently than ever before. Now, researchers have demonstrated another use for the CRISPR complex: changing what genes are expressed without altering the genome itself. For the first time, researchers at the Salk Institute in San Diego were able to use CRISPR to activate beneficial genes in live mice suffering from muscular dystrophy, Type 1 diabetes and acute kidney injury.

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