Early Embryos Kept in Check
December 1, 2017
(Nature) – Shahbazi et al. used their ex utero culture systems to study the coordination between the exit from pluripotency and the formation of the amniotic cavity. First, the authors noticed that the downregulation of pluripotency genes coincided with the appearance of the amniotic cavity in both mouse and human embryos. Next, they observed that maintaining pluripotent cells in a naive state in embryos by artificially supplying LIF prevented the cells from forming the amniotic cavity.