Cancer-Genome Study Challenges Mouse ‘Avatars’
October 11, 2017
(Nature) – An analysis of more than 1,000 mouse models of cancer has challenged their ability to predict patients’ response to therapy. The study, published today in Nature Genetics catalogues the genetic changes that occur in human tumours after they have been grafted into mouse hosts. Such models, called patient-derived xenografts (PDXs), are used in basic research and as ‘avatars’ for individual patients. Researchers use these avatar mice to test a bevy of chemotherapies against a person’s tumour, in the hope of tailoring a treatment plan for the patient’s specific cancer.