We’re Nearly Ready to Use CRISPR to Target Far More Diseases
October 4, 2017
(New Scientist) – The big challenge is delivering the CRISPR machinery to tissues inside the body. Editing genes with CRISPR requires at least two components: a protein that cuts DNA and a piece of RNA that guides it to the precise DNA site to make the cut. Proteins and RNAs are enormous molecules compared with conventional drugs. It’s hard to get them inside cells, and they don’t usually survive in the bloodstream, either.