Authors Retract Controversial NgAgo Gene-Editing Study

August 9, 2017

(Nature) – The Chinese authors of a high-profile gene-editing paper retracted their study yesterday, citing scientists’ inability to replicate the main finding. The paper, published in Nature Biotechnology in May 2016, detailed how an enzyme named NgAgo could be used to knock out or replace genes in human cells by making incisions at precise points on the DNA. The study promised a more versatile alternative to the now ubiquitous CRISPR–Cas9 gene-editing system, which has revolutionized molecular biology and has even been used to fix genes for a heritable heart condition in human embryos.

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